Health Care Law by Jonathan Montgomery has much to recommend it. It is a comprehensive account of the law relating to health care in its broadest sense. From the outset, Montgomery sets his face against a narrow construction of his task; as he recognises, health care law is so much more than the "law relating to what doctors do".

This work is a revised presentation of Kupczak’s dissertation, The Human Person as an Efficient Cause in the Christian Anthropology of Karol Wojtyla. It is introduced by Michael Novak’s article, “The Christian Philosophy of John Paul II”, which serves as an excellent entrée to Kupczak’s analysis of Wojtyla’s system.

This work is largely based on Reimers’s doctoral dissertation, written under Rocco Buttiglione, an Italian philosopher and close collaborator of Wojtyla. In essence, however, it is less a focussed study of the thought of Karol Wojtyla than an attempt to insert that thought into a different conceptual context and to illuminate it by way of comparison and synthesis. The analogue to Wojtyla’s thought, in this case, is that of C. S. Peirce. Peirce’s analysis of habit, as a kind of major (...) premise or a sign of the meaning of an action, is compared to Wojtyla’s more dynamic approach to the relationship between act and meaning, in Reimers’s characterization, “as the moment of experience of choice”. (shrink)

The Heythrop Journal, Volume 63, Issue 4, Page 807-816, July 2022.

With his clear and accessible prose, impeccable scholarship, and balanced Judgment, Roland Teske, SJ, has been an influential and important voice in Medieval philosophy for more than thirty years. This volume, in his honour, brings together more than a dozen essays on central metaphysical and theological themes in Augustine and other medieval thinkers. The authors, listed below, are noted scholars who draw upon Teskes work, reflect on it, go beyond it, and at times even disagree with it, but always (...) in a spirit of respectful co-operation, and always with the aim of getting at the truth. Essays on Augustine contributed by Gerald Bonner, Charles Brittain, Joseph Koterski, SJ, Joseph T. Lienhard, SJ, David Vincent Meconi, SJ, Ann A. Pang-White, Frederick Van Fleteren, Dorothea Weber, and James Wetzel. Essays on Bernard of Clairvaux, William of Auvergne, and other medieval themes contributed by John P. Doyle, William Harmless, SJ, John A. Laumakis, Edward P. Mahoney, and Philipp W. Rosemann. (shrink)

Although activated spinal cord glia contribute importantly to neuropathic pain, how nerve injury activates glia remains controversial. It has recently been proposed, on the basis of genetic approaches, that toll-like receptor 4 may be a key receptor for initiating microglial activation following L5 spinal nerve injury. The present studies extend this idea pharmacologically by showing that TLR4 is key for maintaining neuropathic pain following sciatic nerve chronic constriction injury. Established neuropathic pain was reversed by intrathecally delivered TLR4 receptor antagonists derived (...) from lipopolysaccharide. Additionally, -naltrexone, -naloxone, and -naloxone, which we show here to be TLR4 antagonists in vitro on both stably transfected HEK293-TLR4 and microglial cell lines, suppressed neuropathic pain with complete reversal upon chronic infusion. Immunohistochemical analyses of spinal cords following chronic infusion revealed suppression of CCI-induced microglial activation by -naloxone and -naloxone, paralleling reversal of neuropathic pain. Together, these CCI data support the conclusion that neuron-to-glia signaling through TLR4 is important not only for initiating neuropathic pain, as suggested previously, but also for maintaining established neuropathic pain. Furthermore, these studies suggest that the novel TLR4 antagonists -naloxone and -naloxone can each fully reverse established neuropathic pain upon multi-day administration. This finding with -naloxone is of potential clinical relevance. This is because -naloxone is an antagonist that is inactive at the -opioid selective receptors on neurons that produce analgesia. Thus, these data suggest that -opioid antagonists such as -naloxone may be useful clinically to suppress glial activation, yet -opioid agonists suppress pain. (shrink)

The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of Abeta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. (shrink)

This volume provides a concentrated and powerful dialog about the nexus between schools, prisons, and the free-market economy where youth are on fast tracks from schools to prisons.

(Report assembled for the Workshop of the AMIA Working Group on Formal Biomedical Knowledge Representation in connection with AMIA Symposium, Washington DC, 2005.) Best practices in ontology building for biomedicine have been frequently discussed in recent years. However there is a range of seemingly disparate views represented by experts in the field. These views not only reflect the different uses to which ontologies are put, but also the experiences and disciplinary background of these experts themselves. We asked six questions related (...) to biomedical ontologies to what we believe is a representative sample of ontologists in the biomedical field and came to a number conclusions which we believe can help provide an insight into the practical problems which ontology builders face today. (shrink)

Many writers have been struck by what Ronald Melzack, a leading investigator of pain mechanisms, calls the ‘puzzle’ of pain. Thus the surgeon Leriche, often quoted in this connection, says: Defence reaction? Fortunate warning? But as a matter of fact the majority of illnesses, even the most serious, attack us without warning. Sickness is nearly always a drama in two acts, of which the first takes place, cunningly enough, in the dim silence of bur tissues, with the lights out, before (...) the candles have been lit. When pain makes its appearance, we are almost in the second act…… Pain merely makes more distressing and sad a situation already long lost…… In fact, pain is always a baleful gift, which reduces the subject of it, and makes him more ill than he would be without it. (shrink)

In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this (...) review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen. (shrink)

The word “real” (from the Latin “res” = thing) was coined in the 13th century to signify “having Properties” (Pierce. 1958, p. 358), whereas a “model” refers to an analogical representation, the structure of which should correspond to the structure or properties of that which it represents. For Scudder the mind is a system of models and each mind develops different models. We all have a different reality in mind and so we each live in a slightly different world (Scudder, (...) 1975). Hence the real nature of the model and the model nature of reality are often indistinguishable. A snail, for example, when exposed to four tactile stimuli per second (with a rod on his belly) will be compelled to crawl upon that non-existing coherent spatial surface (Brecher, 1966). For the snail four tactile stimuli per second correspond to, or are isomorphic with, the structure of a spatial surface, but it is impossible for the snail to “know” which of the two structures is real. (shrink)

Roland Barthes, the French critic and semiotician, was one of the most important critics and essayists of this century. His work continues to influence contemporary literary theory and cultural studies. Image-Music-Text collects Barthes's best writings on photography and the cinema, as well as fascinating articles on the relationship between images and sound. Two of Barthes's most important essays, "Introduction to the Structural Analysis of Narrative" and "The Death of the Author" are also included in this fine anthology, an excellent (...) introduction to his thought. These essays, as selected and translated by Stephen Heath, are among the finest writings Barthes ever published on film and photography, and on the phenomena of sound and image. The classic pieces "Introduction to the Structural Analysis of Narrative" and "The Death of the Author" are also included. (shrink)

The concept of hope—as used in ordinary language in assertions of (for example) the form ›Person S hopes that p‹—can be analysed in terms of belief, desire, and, as I claim, affective quality. According to my analysis, one feature of hope is that what S hopes for has some subjective probability for S. Hope thus has an epistemic component on which demands of rationality can be (and, as a matter of fact, are) placed. Ordinary language distinguishes various types of deficient (...) hoping. On the basis of my explication of ›hope‹, it can be shown that types of deficient hope differ in the way in which they violate rationality. A particularly interesting type of deficient hoping is self-deceptive hope. Self-deception centrally involves the formation or retention of beliefs under the influence of biasing motivational factors. And hope, through its conative component, contains just such a motivation for self-deception. Hope is thus closely, if only contingently, connected with self-deception: not all hope is self-deceptive, but it is natural and presumably rather common for hopes to involve self-deception. Hope’s susceptibility to self-deception is one of the primary reasons why hope has been the subject of ambivalent or even negative valuation, the main conflict being the one between (important) benefits of hoping and the value of truth. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:94. THE HUME LITERATURE FOR 1976 A fairly complete coverage of the recent Hume literature up to 1970 is available in my booklet, A Hume Bibliography from 1930 (York, 1971; obtainable direct from the author, post free, on payment of jé 1.25 within the U.K., c^3.00 or $8.00 elsewhere). Coverage up to 1975 is obtained when this is combined with the addenda and supplement published in the Philosophical Quarterly (...) in January 1976. What follows here will bring the record up to the end of 1976. Readers are invited to inform me of any omissions. The intention is to maintain a complete bibliographical record of critical work on Hume, by the regular publication in Hume Studies of an annual bibliography covering the previous year. In a forthcoming book (Edinburgh University Press; probable title, Fifty Years of Hume Scholarship) I have tried to provide all that the student of Hume needs as a guide to the secondary literature: an introductory essay on the development of Hume scholarship up to the present time, thorough coverage of the Hume literature from 1925 to 19 76, with indexing by author, language, and subject, and also a list of the main writings on Hume earlier this century. The following abbreviations of journal titles have been used: APQ American Philosophical Quarterly JHI Journal of the History of Ideas JHP Journal of the History of Philosophy JP Journal of Philosophy PAS Proceedings of the Aristotelian Society PB Philosophical Books PBA Proceedings of the British Academy PQ Philosophical Quarterly PR Philosophical Review RIP Revue Internationale de Philosophie 95. RM Review of Metaphysics TLS Times Literary Supplement Other abbreviations should be obvious. ALEJANDRO, de, J. M. 'El atomismo gnoseologico de David Hume (1711-1776)', Pensamiento 32, 383-403. ANDERSON, R. F. 'The Location, Extension, Shape, and Size of Hume's Perceptions', in Livingston & King (see below), 153-71. ARDAL, P. S. 'Some Implications of the Virtue of Reasonableness in Hume's Treatise', in Livingston & King, 91-106. ARDLEY, G. 'Hume's Common Sense Critics', RIP 30, 104-2 5. ATKINSON, R. F. 'Hume on the Standard of Morals', in Merrill & Shahan (see below), 25-44. BAGOLINI, L. David Hume e Adam Smith: Elementi per una ricerca di filosofia giuridica e politica. Bologna. BAYLES, M. D. 'Hume on Blame and Excuse', Hume Studies 2, 17-35. BEANBLOSSOM, R. E. 1A New Foundation for Humean Scepticism1, Phil. Studies 29, 207-10. BEAUCHAMP, T. L. 'An Analysis of Hume's Essay "On Suicide"', RM 30, 73-95. BERfIAN, D. "David Hume on the 1641 Rebellion in Ireland', Studies: a Quarterly Review 65, 101-102. BIRO, J. I. 'Hume on Self-Identity and Memory", RM 30, 19-38. BJELKE, J. F. 'Wirklichkeitserkenntnis und Wirklichkeitsimagination bei Hume', Archiv für Geschichte der Phil. 58, 23-39. BOATRIGHT, J. R. 'Hume's Account of Moral Sentiment", RIP 30, 79-90. BOSSERT, P. J. "Hume and Husserl on Time and Time-Consciousness ", J. Br. Soc. Phenomenol. 7, 44-52. 96. BURNS, S. "The Humean Female", Dialogue 15, 415-2 4. [425-40.] BUTLER, R. J. ' Distinctiones Rationis, or the Cheshire Cat which left its smile behind it", PAS 76, 165-76. BUTLER, R. J. 'Hume's Impressions', in Royal Inst, of Phil. Lectures, Vol. 9, 122-36. CAPALDI, N. 'Hume's Theory of the Passions', in Livingston & King, 172-90. CHERRY, C. 'Nature, artifice and moral approbation", PAS 76, 265-82. COHEN, R. 'The Rationale of Hume's Literary Inquiries', in Merrill & Shahan, 97-115. COLVER, A. W. David Hume, The Natural History of Religion and PRICE, J. V. David Hume, Dialogues concerning Natural Religion. Oxford. [PB_ 18 (1977), 49-54. ] COURTENAY, W. J. et al. Ockham, Descartes, and Hume: Self-Knowledge, Substance, and Causality. Madison, Wis. CONNON, R. W. 'Some Hume MS Alterations on a Copy of the Abstract', JHP 14, 353-6. DAVIDSON, D. 'Hume's cognitive theory of pride', JP- 73, 744-57. DAVIE, W. 'Hume's Catalog of Virtue and Vice', in Merrill & Shahan, 45-57. DERATHÉ, R. 'L'obligation politique selon Hume', RIP 30, 91-103. ESPOSITO, J. L. 'Hume and the Transcendental Idealists', Southern J. Phil. 14, 431-42. FALK, W. D. 'Hume on Is and Ought', Canadian J... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:172. THE HUME LITERATURE FOR 1981 The Hume literature from 1925 to 1976 has been thoroughly covered in my book Fifty Years of Hume Scholarship : A Bibliographical Guide (Edinburgh University Press, 1978; jê9.50), which also lists the main earlier writings on Hume. Publications of the years 1977 to 1980 were listed in Hume Studies for the last four Novembers. What follows here will bring the record up to (...) the end of 1981. Readers are invited to inform me of any omissions, and to send me offprints of their own articles and reviews. The intention is to maintain a complete bibliographical record of critical work on Hume, by the regular publication in Hume Studies of an annual bibliography covering the previous year, with addenda consisting of items omitted through ignorance in previous years. References to recently-appearing reviews (of books from earlier lists) are given at the end. The following abbreviations of journal titles are used here: APQAmerican Philosophical Quarterly JHIJournal of the History of Ideas JHPJournal of the History of Philosophy JPJournal of Philosophy PASProceedings of the Aristotelian Society PBPhilosophical Books PQPhilosophical Quarterly PRPhilosophical Review RIPReview Internationale de Philosophie RMReview of Metaphysics TLSTimes Literary Supplement Other abbreviations should be obvious enough, and mainly fol· low the British Standard (no. 4148). BAGOLINI, L. 'Legal Obligation in Hume', Hume Studies 7, 85-93. BAIER, A. 'Frankena and Hume on Points of View', The Monist 64, 342-58. BATTERSBY, C. 'An Enquiry concerning the Humean Woman', Philosophy 56, 303-12. 173. BEAUCHAMP, T. L. & ROSENBERG, A. Hume and the Problem of Causation, (xxv, 340 pp.) New York. [PB 23 (1982) 129-48 (Mackie, Flew, Beauchamp & Rosenberg) ] BOTWINICK, A. 'Hume on Is-Ought', Auslegung 8, 19-30. BURNS, R. M. The Great Debate on Miracles, esp. chs. 6-8. Lewisburg, London & Toronto. COSTA, M. J. 'Hume and Justified Belief, Can. J. Phil. 11, 219-28. CRONIN, R. Shelley's Poetic Thoughts, 77-83. London. DE MARTELAERE, P. 'Hume's "Gematigd" Scepticisme: Futiel of Fataal', Tijdschrift voor Filosofie 43, 427-64. DILMAN, I. Studies in Language and Reason, chs. 4-5. London. FARR, W. Hume and Kant: Studienbuch zum Erkenntsnisproblem. (250 pp.) Freiburg & Munich. FEINSTEIN, R. 'Some Problems in Humean Philosophy', Ind. phil. Q. 8, 527-32. FLAGE, D. E. 'Hume's Relative Ideas', Hume Studies 7, 55-73. GARCIA ROCA, J. Positivismo e Ilustración : La filosofía de David Hume. (304 pp.) Valencia. GARRETT, D. 'Hume's Self-Doubts about Personal Identity', PR 90, 337-58. GUPTA, B. 'Scepticism: Ancient "East" and Modern "West"', Ind. phil. Q. 9, 29-44. HAAKONSSEN, K. The Science of a Legislator, the Natural Jurisprudence? of David Hume and Adam Smith. Cambridge. HALL, R. 'The Hume Literature for 1980', Hume Studies 7, 184-90. íiARRISON, J. Hume's Theory of Justice. (xxvi, 304 pp.) Oxford. [THES no. 440 (3 Apr. 1981) 15] IMLAY, R. A. 'Hume's Of Scepticism with regard to reason: A Study in Contrasting Themes', Hume Studies 7, 121-36. JOHNSON, 0. A. 'Hume's "True" Scepticism', Pacific phil. Q. 62, 403-10. JONES, G. E. 'Vindication, Hume, and Induction', Can. J. Phil. 12, 119-29. 174. KING, J. 'Hume's Classical Theory of Justice', Hume Studies 7, 32-54. KULENKAMPFF, J. 'David Hume (1711-1776)', in 0. Hoffe, Klassiker der Philosophie, vol. 1, 434-56. Munich. LOEB, L. E. From Descartes to Hume, sec. 39 (354-63). Ithaca & London. MACLEOD, A. "Rule-Utilitarianism and Hume's Theory of Justice', Hume Studies 7, 74-84. MAHER, P. 'Probability in Hume's Science of Man', Hume Studies 7, 137-53. MALHERBE, M. 'Les études humiennes: anatomie et problèmes1, Archives de Philosophie 44, 637-71. MILLER, D. Philosophy and Ideology in Hume's Political ThoughtT (218 pp.) Oxford. [London Rev, of Bks 4 (1982), no. 7, 22-4; PB 23 (1982) 206-9] MONTEIRO, J. P. 'Hume's Conception of Science', JHP 19, 327-42. NEWMAN, R. 'Hume on Space and Geometry', Hume Studies 7, 1-31. NIELSON, H. A. 'Inference and Experience in Hume's Enquiry', Phil. Res. Archives 7, no. 1471. NORTH, T. 'What if I'm Indifferent?', Phil. Investigations 4, 24-37. PAPPAS, G. S. 'On McRae's Hume', Hume Studies... (shrink)

RésuméĽétude du développement?on;un organisme fait appel à diverses approches choisies en fonction des objectifs fixés par ľexpérimentateur. Ainsi, la mise en évidence?on;une corrélation entre deux paramétres, par exemple biochimique et morphologique, permet de les considérer comme associés, sans nécessairement dégager entre eux un lien direct de causalité. Ce dernier peut être explicité par une autre approche, comme ľillustre une étude portant sur la relation entre une enzyme ‐glycohydrolase) et la différentiation sporale chez Neurospora crassa.SummaryThe study of the development of an (...) organism requires diverse approaches selected on the basis of experimental objectives. For instance, the finding of a correlation between two parameters, i.e. biochemical and morphological, allows them to be considered as associated without necessarily pointing to a direct causal relationship. This latter may be brought out by another approach, as illustrated by this study bearing on the relation between an enzyme ‐gly‐cohydrolase) and differentiation of spores in Neurospora crassa.ZusammenfassungDas Studium der Entwicklung eines Organismus erfordert verschiedenartige Annäherungen, je nach den vom Experimendierenden gestellten Ziele. Daher erlaubt der Nachweis einer Korrela‐tion zwischen zwei Parametern, zum Beispiel einem biochemischen und einem morphologischen, sie als verbunden zu betrachten ohne notwendigerweise eine Kausalbeziehung zwischen Ihnen zu beweisen. Eine solche kann von einer anderen Seite geklärt werden, wie es eine Studie der Beziehung zwischen einem Enzym ‐glycohydrolase) und der Sporendifferenzierung bei Neurospora crassa zeigt. (shrink)